Association of Anatomical Pathology Technology

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Tissue-specific tolerance in fatal Covid-19

Hyper-inflammation occurs in Covid-19 and is associated with worse outcomes



Successful host defence against a pathogen can involve resistance or tolerance, with implications for prioritising either antimicrobial or immunomodulatory therapeutic approaches. Hyper-inflammation occurs in Covid-19 and is associated with worse outcomes.

The efficacy of dexamethasone in preventing mortality in critical Covid-19 suggests that inflammation has a causal role in death.

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2020

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